Haruki, M., Matsumoto, R., Hara-Yokoyama, M., Miyazawa, T. and Yokoyama, S., "Conformational changes of aminoacyl-tRNA and uncharged tRNA upon complex formation with polypeptide chain elongation factor Tu", FEBS Lett., 263, 361-364 (1990).

Kohno, T., Kohda, D., Haruki, M., Miyazawa, T. and Yokoyama,S., "Nonprotein amino acid furanomycin, unlike isoleucine in chemical structure, is charged to isoleucine tRNA by isoleucyl-tRNA synthetase and incorporated into protein", J. Biol. Chem., 265, 6931-6935 (1990).

Haruki, M., Noguchi, E., Nakai, C., Liu, Y.-Y., Oobatake, M., Itaya, M. and Kanaya, S., "Investigating the role of conserved residue Asp134 in Escherichia coli ribonuclease HI by site-directed random mutagenesis", Eur. J. Biochem., 220, 623-631 (1994).

Haruki, M., Noguchi, E., Akasako, A., Oobatake, M., Itaya, M. and Kanaya, S., "A novel strategy for stabilization of Escherichia coli ribonuclease HI involving a screen for an intragenic suppressor of carboxyl-terminus deletions", J. Biol. Chem., 269, 26904-26911 (1994).

Akasako, A., Haruki, M., Oobatake, M. and Kanaya, S., "High resistance of Escherichia coli ribonuclease HI variant with quintuple thermostabilizing mutations to thermal denaturation, acid denaturation, and proteolytic degradation", Biochemistry, 34, 8115-8122 (1995).

Healy, J.M., Haruki, M. and Kikuchi, M., "Preferred motif for integlin binding identified using a library of randomized RGD peptides displayed on phage", Protein Peptide Lett., 3, 23-30 (1996).

Kashiwagi, T., Jeanteur, D., Haruki, M., Katayanagi, K., Kanaya, S. and Morikawa, K, "Propose of new catalytic roles for two invariant residues in Escherichia coli ribonuclease HI", Protein Eng.,, 9, 857-867 (1996).

Fujiwara, S., Lee, S.G., Haruki, M., Kanaya, S., Takagi, M. and Imanaka, T., "Unusual enzyme characteristics of aspartyl-tRNA synthetase from hyperthermophilic archaeon Pyrococcus sp. KOD1", FEBS Lett., 394, 66-70 (1996).

Akasako, A., Haruki, M., Oobatake, M. and Kanaya, S.", Conformational stabilities of Escherichia coli ribonuclease HI variants with a series of amino acid substitutions at a cavity within the hydrophobic core", J. Biol. Chem., 272, 18686-18693 (1997).

Haruki, M., Noguchi, E., Kanaya, S. and Crouch, R.J.,"Kinetic and stoichiometric analysis for the binding of Escherichia coli ribonuclease HI to RNA-DNA hybrids using surface plasmon resonance", J. Biol. Chem., 272, 22015-22022 (1997).

Hirano, N., Haruki, M., Morikawa, M., and Kanaya, S, "Stabilization of ribonuclease HI from Thermus thermophilus HB8 by the spontaneous formation of an intramolecular disulfide bond", Biochemistry, 37, 12640-12648 (1998).

Haruki, M., Hayashi, K., Kochi, T., Muroya, A., Koga, Y., Morikawa, M., Imanaka, T., and Kanaya, S.,, "Gene cloning and characterization of recombinant ribonuclease HII from a hyperthermophilic archaeon", J. Bacteriol., 180, 6207-6214 (1998).

Koga, Y., Morikawa, M., Haruki, M., Nakamura, H., Imanaka, T., and Kanaya, S., "Thermostable glycerol kinase from a hyperthermophilic archaeon: Cloning of the gene, overexpression in E. coli and characterization of the enzyme", Protein Eng., 11, 1219-1227 (1998).

Ohtani, N., Haruki, M., Morikawa, M., Crouch, R.J., Itaya, M., and Kanaya., S., "Identification of the genes encoding Mn²⁺-dependent RNase HII and Mg²⁺-dependent RNase HIII from Bacillus subtilis: Classification of RNases H into three families", Biochemistry, 38, 605-618 (1999).

Okibe, N., Amada, K., Hirano, S., Haruki, M., Imanaka, T., Morikawa, M., and Kanaya., S., "Gene cloning and characterization of aldehyde dehydrogenase from a petroleum degrading bacterium strain HD-1", J. Biosci. Bioeng., 88, 7-11 (1999).

Ohtani, N., Haruki, M., Morikawa, M., and Kanaya., S., "Molecular diversities of RNases H", J. Biosci. Bioeng., 88, 12-19 (1999).

Huy, N.Q.,Jin, S., Amada, K., Haruki, M., Huu, N.B., Hang, D.T., Ha, D.T.C., Imanaka, T, Morikawa, M., and Kanaya., S., "Characterization of petroleum-degrading bacteria from oil-contaminated sites in Vietnam", J. Biosci. Bioeng., 88, 100-102 (1999).

Haruki, M., Oohashi, Y., Mizuguchi, S., Matsuo, Y., Morikawa, M., and Kanaya, S., "Identification of catalytically essential residues in Escherichia coli esterase by site-directed mutagenesis", FEBS Lett., 454, 262-266 (1999).

Matsuda, T., Morikawa, M., Haruki, M., Higashibata, H., Imanaka, T., and Kanaya, S., "Isolation of TBP-interacting protein (TIP) from a hyperthermophilic archaeon that inhibits the binding of TBP to TATA-DNA" FEBS Lett., 454, 38-42 (1999).

Mizuguchi, S., Amada, K., Haruki, M.,Imanaka, T., Morikawa, M., and Kanaya, S., "Identification of the Gene Encoding Esterase, a Homolog of Hormone-Sensitive Lipase, from an Oil-Degrading Bacterium, Strain HD-1", J. Biochem., 126, 731-737 (1999).

Ohtani, N., Haruki, M., Muroya, A., Morikawa, M., and Kanaya, S., "Characterization of ribonuclease HII from Escherichia coli overproduced in a soluble form", J. Biochem., 126, 895-899 (2000).

Amada, K., Haruki, M., Imanaka, T., Morikawa, M., and Kanaya, S., "Overproduction in Escherichia coli, purification and characterization of a family I.3 lipase from Pseudomonas sp. MIS38", Biochim Biophys Acta., 1478, 201-210 (2000).

Hirano, N., Haruki, M., Morikawa, M., and Kanaya, S., "Enhancement of the enzymatic avtivity of ribonuclease HI from Thermus thermophilus HB8 with a suppressor mutation method", Biochemistry, 39, 13285-13294 (2000).

Haruki, M., Tsunaka, Y., Morikawa, M., Iwai, S., and Kanaya, S., "Catalysis by Escherichia coli ribonuclease HI is facilitated by a phosphate group of the substrate", Biochemistry, 39, 13939-13944 (2000).

Kwon, H.-J., Amada, K., Haruki, M., Morikawa, M. and Kanaya, S., "Identification of the histidine and aspartic acid residues essential for enzymatic activity of a family I.3 lipase by site-directed mutagenesis" , FEBS lett., 483, 139-142 (2000).

Haruki, M., Nogawa, T., Hirano, N., Chon, H., Tsunaka, Y.,Morikawa, M. and Kanaya, S., "Efficient cleavage of RNA at high temperatures by a thermostable DNA-linked ribonuclease H", Protein Eng., 13, 881-886 (2000).

Kato, T., Haruki, M., Imanaka, T., Morikawa, M. and Kanaya, S., "Isolation and characterization of long-chain-alkane degrading Bacillus thermoleovorans from deep subterranean petroleum resorvoir", J. Biosci. Bioeng., 91, 64-70 (2001).

Kato, T., Miyanaga, A., Haruki, M., Imanaka, T., Morikawa, M. and Kanaya, S., "Gene cloning of an alcohol dehydrogenase from thermophilic alkane degrading Bacillus thermoleovorans B23", J. Biosci. Bioeng., 91, 100-102 (2001).

Kato, T., Haruki, M., Imanaka, T., Morikawa, M. and Kanaya, S., "Isolation and characterization of psychrotrophic bacteria from oil resorvoir water and oil sands", Appl. Microbial. Biotechnol., 55, 794-800 (2001).

Muroya, A., Tsuchiya, D., Ishikawa, M., Haruki, M., Morikawa, M., Kanaya, S. and Morikawa, K., "Catalytic center of an archaeal Type 2 ribonuclease H as revealed by X-ray crystallogrophic and mutational analyses", Protein Science, 10, 707-714 (2001).

Tsunaka, Y., Haruki, M., Morikawa, M. and Kanaya, S., "Strong nucleic acid binding to the E.coli RNase HI mutant with two arginine residues at the active site", Biochim. Biophys. Acta, 1547, 135-142 (2001).

Matsuda, T., Fujikawa, M., Haruki, M., Tang, X.-F., Ezaki, S., Imanaka, T., Morikawa, M. and Kanaya, S, "Interaction of TIP26 from a hyperthermophilic archaeon with TFB/TBP/DNA ternary complex", Extremophiles, 3, 177-2182 (2001).

Koga, Y., Haruki, M., Morikawa, M. and Kanaya, S., "Stabilities of chimeras of hyperthermophilic and methphilic glycerol kinases constructed by DNA shuffling", J. Biosci. Bioeng., 91, 551-556 (2001).

Kannan,Y., Koga, Y., Inoue,Y., HarukiI, M., Takagi, M., Imanaka, T., Morikawa, M. and Kanaya, S., "Active subtilisin-like protease from a hyperthermophilic archaeon in a form with a putative prosequence", Appl. Environ. Microbiol., 67, 2445-2452 (2001).

Amada, K., Kwon, H.-J., Haruki, M., Morikawa, M. and Kanaya, S., "Ca2+-induced folding of a family I.3 lipase with repetitive Ca2+ binding motifs at the C-terminus", FEBS Lett. 509, 17-21 (2001).

Ohtani, N., Haruki, M., Morikawa, M. and Kanaya, S., "Heat labile ribonuclease HI from a psychrotrophic bacterium: gene cloning, characterization, and site-directed mutagenesis," Protein Engineering, 14, 975-982 (2001).

Kwon, H-J., Haruki, M., Morikawa, M., Omori, K. and Kanaya, S., "Role of repetitive nine-residue sequence motifs on secretion, enzymatic activity, and protein conformation of a family I.3 lipase", J. Biosci. Bioeng., 93, 157-164 (2002).

Muroya, A., Nakano, R., Ohtani, N., Haruki, M., Morikawa, M. and Kanaya, S., "Importance of an N-terminal extension of ribonuclease HII from Bacillus stearothermophilus for substrate binding", J. Biosci. Bioeng., 93, 170-175 (2002).

Chon, H., Tsunaka, Y., Haruki, M., Morikawa, M. and Kanaya, S., "Site-specific cleavage of MS2 RNA by a thermostable DNA-linked RNase H", Protein Engineering., 15, 683-688 (2002).

Haruki, M., Tsunaka, Y., Morikawa, M., Kanaya, S., "Cleavage of a DNA-RNA-DNA/DNA chimeric substrate containing a single ribonucleotide at the DNA-RNA junction with prokaryotic RNases HII", FEBS Lett., 531, 204-208 (2002).

Roongsawang, N., Thaniyavarn, J., Thaniyavarn, S., Kameyama, T., Haruki, M., Imanaka, T., Morikawa, M., Kanaya, S., "Isolation and characterization of a halotolerant Bacillus subtilis BBK-1 which produces three kinds of lipopeptides: bacillomycin L, plipastatin, and surfactin, Extremophiles, 6, 499-506 (2002).

Tsunaka, Y., Haruki, M., Morikawa, M., Oobatake, M., Kanaya, S., "Dispensability of Glu48 and Asp134 for Mn2+-dependent activity of E. coli Ribonuclease HI", Biochemistry, 42, 3366-3374 (2003).

Thaniyavarn, J., Roongsawang, N., Kameyama, T., Haruki, M., Imanaka, T., Morikawa, M., Kanaya, S., "Production and characterization of biosurfactants from Bacillus licheniformis F2.2", Biosci.Biotechnol.Biochem., 67, 1239-1244 (2003).

Roongsawang, N., Hase, K., Haruki, M., Imanaka, T., Morikawa, M., Kanaya, S., "Cloning and characterization of the gene cluster encoding arthrofactin synthetase from Pseudomonas sp. MIS38", Chem Biol., 10, 869-880 (2003).

Hirano, S., Kitauchi, F., Haruki, M., Imanaka, T., Morikawa, M., Kanaya, S., "Isolation and Characterization of Xanthobacter polyaromaticivorans sp. nov. 127W That Degrades Polycyclic and Heterocyclic Aromatic Compounds under Extremely Low Oxygen Conditions", Biosci. Biotechnol. Biochem., 68, 557-64 (2004).

Suzuki, Y., Haruki, M., Takano, K., Morikawa, M., Kanaya, S., "Possible involvement of an FKBP family member protein from a psychrotrophic bacterium Shewanella sp. SIB1 in cold-adaptation", Eur. J. Biochem., 271, 1372-81 (2004).

Cornista, J., Ikeuchi S, Haruki, M., Kohara, A., Takano, K., Morikawa, M., Kanaya, S., "Cleavage of various peptides with pitrilysin from Escherichia coli: kinetic analyses using beta-endorphin and its derivatives", Biosci.Biotechnol.Biochem., 68, 2128-37(2004).

Chon, H., Nakano, R., Ohtani, N., Haruki, M.,Takano, K., Morikawa, M., Kanaya, S., "Gene cloning and biochemical characterizations of thermostable ribonuclease HIII from Bacillus stearothermophilus", Biochemistry., 68, 2138-47(2004).

Mukaiyama, A.,Takano, K., Haruki, M., Morikawa, M., Kanaya, S., "Kinetically robust monomeric protein from a hyperthermophile.", Biochemistry, 43, 13859-66(2004).

Kunihiro, N., Haruki, M.,Takano, K., Morikawa, M., Kanaya, S., "Isolation and characterization of Rhodococcus sp. strains TMP2 and T12 that degrade 2,6,10,14-tetramethylpentadecane (pristane) at moderately low temperatures", J. Biotechnol., 115, 129-36(2004).

Suzuki, Y., Mizutani, Y., Tsuji ,T., Ohtani, N., Takano, K., Haruki, M., Morikawa, M., Kanaya, S., "Gene cloning, overproduction, and characterization of thermolabile alkaline phosphatase from a psychrotrophic bacterium", Biosci Biotechnol Biochem., 69, 364-373 (2005).

Kitauchi, F., Hirano, S., Haruki, M., Imanaka, T., Morikawa, M., Kanaya, S., "Comparison of dibenzothiophene-degrading bacteria under low oxygen conditions", J. Environ. Biotech., 4, 117-120 (2005).

Hirano, S.I., Haruki, M., Takano, K., Imanaka, T., Morikawa ,M., Kanaya, S., "Gene cloning and in vivo characterization of a dibenzothiophene dioxygenase from Xanthobacter polyaromaticivorans", Appl. Microbiol. Biotechnol., 69, 672-681 (2006).

Haruki, M., Saito, Y., Ota, M., Nishikawa, K., Kanaya, S. , "Stabilization of E. coli Ribonuclease HI by the ‘stability profile of mutant protein’ (SPMP)-inspired random and non-random mutagenesis", J. Biotechnol., 124, 512-522 (2006).

Morikawa, M., Kagihiro, S., Haruki, M., Takano, K., Branda, S., Kolter, R., Kanaya, S., "Biofilm formation by a Bacillus subtilis strain that produces gamma-polyglutamate", Microbiology, 152, 2801-2807 (2006).

Mukaiyama, A., Haruki, M,. Ota, M., Koga, Y., Takano, K., Kanaya, S., "A Hyperthermophilic Protein Acquires Function at the Cost of Stability", Biochemistry, 45, 12673-12679 (2006).

Haruki, M., Konnai, Y., Shimada, A., Takeuchi, H., "Molecularly Imprinted Polymer-Assisted Refolding of Lysozyme", Biotechnol. Prog., 23, 1254-1257 (2007).

Haruki, M., Tanaka, M., Motegi, T., Tadokoro, T., Koga, Y., Takano, K., Kanaya, S., "Structural and thermodynamic analyses of Escherichia coli ribonuclease HI variant with quintuple thermostabilizing mutations", FEBS J., 274, 5815-5825 (2007).

Kobayashi, R., Hirano, N., Kanaya, S., Saito, I., Haruki, M., "Enhancement of the enzymatic activity of Escherichia coli acetyl esterase by random mutagenesis", Journal of Molecular Catalysis B: Enzymatic, 67, 155-161 (2010).

Hirano, N., Muroi, T., Kihara, Y., Kobayashi, R., Takahashi, H., Haruki, M., "Site-specific recombination system based on actinophage TG1 integrase for gene integration into bacterial genomes", Appl. Microbiol. Biotechnol., 89, 1877-1884 (2011).

Hirano, N., Muroi, T., Takahashi, H., and Haruki, M., "Site-Specific Recombinases as Tools for Heterologous Gene Integration", Appl. Microbiol. Biotechnol., 92, 227-239 (2011).

Kobayashi, R., Hirano, N., Kanaya, S. and Haruki, M., “Enhancement of the Enzymatic Activity of Escherichia coli Acetyl Esterase by a Double Mutation Obtained from Random Mutagenesis”, Bioscience, Biotechnology, and Biochemistry, 76, 2082-2086 (2012).

Muroi, T., Kokuzawa, T., Kihara, Y., Kobayashi, R., Hirano, N., Takahashi, H., and Haruki, M., “TG1 Integrase-Based System for Site-Specific Gene Integration into Bacterial Genomes”, Appl. Microbiol. Biotechnol., 97, 4039-4048 (2012).

Yokoyama, M., Haruki, M., Matsuki-Fukushima, M., Nagai-Fuse, M., Fukumoto, M., Narita, T., Okabayashi, K., Sugiya, H., Katsumata-Kato, O., Fujita-Yoshigaki, J., “Effects of [6] - Gingerol on Dedifferentiation of Salivary Acinar Cells”, Int. J. Oral-Med. Sci., 11, 315 -319 (2013).

Hirano, N., Hasegawa, H., Nihei, S., Haruki, M., “Cell-free protein synthesis and substrate specificity of full-length endoglucanase CelJ (Cel9D-Cel44A), the largest multi-enzyme subunit of the Clostridium thermocellum cellulosome”, FEMS Microbiol Lett., 344, 25-30 (2013).

Kihara,Y., Ichikawa, T., Abe, S., Nemoto, N., Ishihara, T., Hirano, N., and Haruki. M., “Synthesis of alkyne-functionalized amphiphilic polysiloxane polymers and formation of nanoemulsions conjugated with bioactive molecules by click reactions”, Polym. J., 46, 175-183 (2014).

Yoshida, H., Haruki, M., Yamagishi, K., “Analysis of Interactions between Mutant Vitamin D Receptor and Its Ligands: Fragment Molecular Orbital Study”, J. Comput. Chem. Jpn., 13/ 6, 305-307, (2014).

Ohtake, K., Yamaguchi, A., Mukai, T., Kashimura, H., Hirano, N., Haruki, M., Kohashi, S., Yamagishi, K., Murayama, K., Tomabechi, Y., Itagaki, T., Akasaka, R., Kawazoe, M., Takemoto, C., Shirouzu, M., Yokoyama, S., and Sakamoto, K., "Protein stabilization utilizing a redefined codon", Scientific Reports, 5, 9762 (2015).

Hirano, K., Nihei, S., Hasegawa, H., Haruki, M., Hirano, N., “Stoichiometric Assembly of the Cellulosome Generates Maximum Synergy for the Degradation of Crystalline Cellulose, as Revealed by In Vitro Reconstitution of the Clostridium thermocellum Cellulosome”, Appl. Environ. Microbiol., 81, 4756-4766 (2015).

Hirano, K., Kurosaki, M., Nihei, S., Hasegawa, H., Shinoda, S., Haruki, M., Hirano, N., "Enzymatic Diversity of the Clostridium thermocellum Cellulosome Is Crucial for the Degradation of Crystalline Cellulose and Plant Biomass", Scientific Reports, 6, 35709(2016).

Kihara,Y., Maeda, R., Imaizumi, A., Ichikawa, T., Nemoto, N., Ishihara, T., Hirano, N., and Haruki. M., “Alkyne-functionalized cationic polysiloxane polymers conjugated with targeting molecules by click reactions for DNA delivery”, J. Nanosci. Nanotech., 17, 5081-5089 (2017).

Shinoda, S., Kurosaki, M., Kokuzawa, T., Hirano, K., Takano, H., Ueda, K., Haruki, M., and Hirano, N., "Comparative Biochemical Analysis of Cellulosomes Isolated from Clostridium clariflavum DSM 19732 and Clostridium thermocellum ATCC 27405 Grown on Plant Biomass", Applied Biochemistry and Biotechnology,187, 994-1010 (2019)

Hirano, K., Saito, T., Shinoda, S., Haruki, M., and Hirano, N., "In Vitro Assembly and Cellulolytic Activity of a Beta-Glucosidase-Integrated Cellulosome Complex", FEMS Microbiol Lett., 366, fnz209 (2019).

Kanto, R., Yonenuma, R., Yamamoto, M., Furusawa, H., Yano, S., Haruki, M., Mori, H., "Mixed Polyplex Micelles with Thermoresponsive and Lysine-based Zwitterionic Shells Derived from Two Poly(Vinyl Amine)-Based Block Copolymer", Langmuir, 37, 3001-3014 (2021).

春木　満、金谷茂則, "ランダム変異導入による蛋白質安定化法", バイオサイエンスとインダストリー, 52, 972-975 (1994).

3. 著書