Ishihara T, Tanaka K, Takafuji A, Miura K, Mizushima T.
Attenuation of LPS-Induced Lung Injury by Benziodarone via Reactive Oxygen Species Reduction
Int. J. Mol. Sci. 24(12), 10035 (2023)
DOI.org/10.3390/ijms241210035

Shibata R, Ishihara T, Tsukamoto T, Oishi Y, Fujimori A, Shibasaki Y.
Synthesis of tetraazacalixarene triazine-containing poly (dimethylsiloxane) with elastic property induced by pinning effect of the calixarene ring
European Polymer J., 162, 110890 (2022)
DOI:10.1016/j.eurpolymj.2021.110890

Kaneko K, Ishihara T.
Development of liver-specific ribavirin-loaded nanoparticles with reduced cytotoxicity
Cogent Medicine, 4 (1): 1418133 (2017)
DOI:10.1080/2331205X.2017.1418133

Kihara Y, Maeda R, Imaizumi A, Ichikawa T, Nemoto N, Ishihara T, Hirano N, and Haruki M.
Alkyne-functionalized cationic polysiloxane polymers conjugated with targeting molecules by click reactions for DNA delivery
J. Nanosci. Nanotechnol. 17, 5081–5089 (2017)
DOI:10.1166/jnn.2017.13121

Ishihara T, Shibui M, Hoshi T, Mizushima T
Scavenging of superoxide anions by lecithinized superoxide dismutase in HL-60 cells
Molecular BioSystems, 12: 274–82　(2016)
DOI:10.1039/c5mb00631g

Ishihara T, Hayashi E, Yamamoto S, Kobayashi C, Tamura Y, Sawazaki R, Tamura F, Tahara K, Kasahara T, Ishihara T, Takenaga M, Fukuda K, Mizushima T.
Encapsulation of beraprost sodium in nanoparticles: Analysis of sustained release properties, targeting abilities and pharmacological activities in animal models of pulmonary arterial hypertension.
J Control Release. 197: 97-104. (2015)
DOI:10.1016/j.jconrel.2014.10.029.

Ishihara T, Kaneko K, Ishihara T, Mizushima T.
Development of biodegradable nanoparticles for liver-specific ribavirin delivery
J Pharm Sci. 103: 4005-4011. (2014)
DOI:10.1002/jps.24219.

Ishihara T, Nara S, Mizushima T.
Interactions of Lecithinized Superoxide Dismutase with Serum Proteins and Cells.　
J Pharm Sci. 103: 1987-1994. (2014)
DOI:10.1002/jps.24031.

Kihara Y, Ichikawa T, Abe S, Nemoto N, Ishihara T, Hirano N, Haruki M.
Synthesis of alkyne-functionalized amphiphilic polysiloxane polymers and formation of nanoemulsions conjugated with bioactive molecules by click reactions.
Polymer Journal 46: 175-183. (2014)
DOI:10.1038/pj.2013.86

Ishihara T, Yamashita Y, Takasaki N, Yamamoto S, Hayashi E, Tahara K, Takenaga M, Yamakawa N, Ishihara T, Kasahara T, Mizushima T.
Prostaglandin E1-encapsulated nanoparticles improve walking activity in an experimental rat model of intermittent claudication,
Journal of Pharmacy and Pharmacology. 65:　1187-94　(2013)

Saito Y, Miyamoto S, Suzuki A, Matsumoto K, Ishihara T, Saito I.
Fluorescent nucleosides with 'on-off' switching function, pH-responsive fluorescent uridine derivatives.
Bioorg Med Chem Lett. 15: 2753-2756. (2012)　

Ayano E, Karaki M, Ishihara T, Kanazawa H, Okano T.
Poly (N-isopropylacrylamide)-PLA and PLA blend nanoparticles for temperature-controllable drug release and intracellular uptake.
Colloids Surf B Biointerfaces. 99:67-73. (2012)

Ishihara T, Kano A, Obara K, Saito M, Chen X, Park TG, Akaike T, Maruyama A.
Nuclear localization and antisense effect of PNA internalized by ASGP-R-mediated endocytosis with protein/DNA conjugates.
J Control Release, 155： 34-39 (2011)

Sakai T, Ishihara T, Higaki M, Akiyama G, Tsuneoka H.
Therapeutic effect of stealth-type polymeric nanoparticles with encapsulated betamethasone phosphate on experimental autoimmune
uveoretinitis.
Invest Ophthalmol Vis Sci., 52: 1516-1521 (2011)

Horie R, Sakamoto T, Nakagawa T, Ishihara T, Higaki M, Ito J.
Stealth-nanoparticle strategy for enhancing the efficacy of steroids in mice with noise-induced hearing loss
Nanomedicine(Lond), 5:1331-40 (2010)

Takenaga M, Ishihara T, Ohta Y, Tokura Y, Hamaguchi A, Igarashi R, Mizushima T.
Nano PGE1 promoted the recovery from spinal cord injury-induced motor dysfunction through its accumulation and sustained release.
J Control. Release, 148： 249-254　(2010)

Ishihara T, Maeda T, Sakamoto H, Takasaki N, Shigyo M, Ishida　T, Kiwada H, Mizushima Y, Mizushima T.
Evasion of the accelerated blood clearance phenomenon by coating of nanoparticles with various hydrophilic polymers
Biomacromolecules, 11：　2700–2706 (2010)

Ishihara T, Mizushima T.
Techniques for efficient entrapment of pharmaceuticals in biodegradable solid micro/nanoparticles (Review article)
Exp. Opinion on Drug Deliv. 7:　565-575　(2010)

Tanaka KI, Ishihara T, Azuma A, Kudoh S, Ebina M, Nukiwa T, Sugiyama Y,　Tasaka Y, Namba T, Ishihara T, Sato K, Mizushima Y, Mizushima T.
Therapeutic effect of lecithinized superoxide dismutase (PC-SOD) on bleomycin-induced pulmonary fibrosis
Am J Physiol Lung Cell Mol Physiol. 298:L348-60 (2010)

Ishihara T, Takahashi M, Higaki M, Mizushima Y, Mizushima T.
Preparation and characterization of a nanoparticulate formulation composed of PEG-PLA and PLA as anti-inflammatory agents
Int. J. Pharm. 385: 170-175 (2010)

Matsuo Y, Ishihara T, Ishizaki J, Miyamoto K, Higaki M, Yamashita N.
Effect of betamethasone phosphate loaded polymeric nanoparticles on a murine asthma model.
Cellular Immunology. 260: 33-38 (2009)

Ishihara T, Takeda M, Sakamoto H, Kimoto A, Kobayashi C, Takasaki N, Yuki K, Tanaka K, Takenaga M, Igarashi R, Higaki M, Maeda T, Yamakawa N, Okamoto Y, Otsuka M, Ishida T, Kiwada H, Mizushima Y, Mizushima T.
Accelerated blood clearance phenomenon upon repeated injection of PEG-modified PLA-nanoparticles.
Pharm. Res. 26: 2270-2279 (2009)

Takeda M, Maeda T, Ishihara T, Sakamoto H, Yuki K, Takasaki N, Nishimura F, Yamashita T, Tanaka KI, Takenaga M, Igarashi R, Higaki M, Yamakawa N, Okamoto Y, Ogawa H, Otsuka M, Mizushima Y, Mizushima T.
Synthesis of Prostaglandin E(1) Phosphate Derivatives and Their Encapsulation in Biodegradable Nanoparticles.
Pharm. Res. 26, 1792-1800 (2009)

Ishihara T, Kubota T, Choi T, Takahashi M, Ayano E, Kanazawa H, Higaki M.
Polymeric nanoparticles encapsulating betamethasone phosphate with different release profiles and stealthiness
Int. J. Pharm. 375: 148-154 (2009)

Ishihara T, Kubota T, Choi T, Higaki M.
Treatment of experimental arthritis with stealth-type polymeric nanoparticles encapsulating betamethasone phosphate
J Pharmacol Exp Ther. 329:412-417 (2009)

Ishihara T, Goto M, Kodera K, Kanazawa H, Murakami Y, Mizushima Y, Higaki M.
Intracellular delivery of siRNA by cell-penetrating peptides modified with cationic oligopeptides
Drug Deliv. 16:152-158 (2009)

Ishihara T, Tanaka K, Tasaka Y, Namba T, Suzuki J, Ishihara T, Okamoto S, Hibi T, Takenaga M, Igarashi R, Sato K, Mizushima Y, Mizushima T.
Therapeutic effect of lecithinized superoxide dismutase (PC-SOD) against colitis.
J Pharmacol Exp Ther. 328:152-164 (2009)

Ishihara T, Goto M, Kanazawa H, Higaki M, Mizushima Y.
Efficient entrapment of poorly water-soluble pharmaceuticals in hybrid nanoparticles
J. Pharm. Sci. 98: 2357-2363 (2009)

Ishihara T, Takahashi M, Higaki M, Mizushima Y.
Efficient encapsulation of a water-soluble corticosteroid in biodegradable nanoparticles.
Int. J. Pharm. 365:200-205 (2009)

Ishihara T, Takahashi M, Higaki M, Takenaga M, Mizushima T, Mizushima Y.
Prolonging the in vivo residence time of prostaglandin E(1) with biodegradable nanoparticles.
Pharm. Res. 25:1686-1695 (2008)